Role of pharmacokinetics and metabolism in drug discovery and development role of pharmacokinetics and metabolism in drug discovery and development role of pharmacokinetics and metabolism in drug discovery and development pharmacol rev 1997 dec494403 49 authors j h lin 1 a y lu affiliation 1 department of drug metabolism merck research laboratory west point pennsylvania 19486 . Discovery and development new drug development can be divided in two different stages discovery and development recently kola and landis13 reviewed the major causes of attrition in development see fig 1 in their review they showed how the root causes of drug failure have evolved over time 1991 2000 in 1991 pk and bioavailability were the major reasons for drug failure 40 . Pharmacokinetics has evolved from its origin into a complex discipline with numerous subspecialties and applications in patient management drug development and regulatory issues this expansion has made it difficult for any one individual to become a full fledged expert in all areas fulfilling the need for a wide ranging guide to the many existing subspecialties in this field . Fulfilling the need for a wide ranging guide to the many existing subspecialties in this field pharmacokinetics in drug discovery and development details the different areas in the field providing the ideal comprehensive quick access text and referenceafter an introduction of basic principles the book is divided into sections that cover industrial and regulatory applications clinical applications and research applications
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